Wednesday, May 18

New genetic clues on multiple sclerosis risk

From left: Gonçalo Castelo-Branco, Eneritz Agirre and Mandy Meijer. Photo: Leslie Kirby.

“Our findings suggest that the risk for multiple sclerosis might manifest by misfunction not only of immune cells, but also of oligodendrocytes and their precursor cells,” says Gonçalo Castelo-Branco, professor at the Department of Medical Biochemistry and Biophysics, Karolinska Institutet, who conducted the study with co-first authors Mandy Meijer, a PhD student, and Eneritz Agirre, a researcher. “These findings indicate that these cells can also be targeted for therapeutical approaches for MS, to prevent misfunction that might be caused by these mutations.”

The study was funded by the European Union Horizon 2020, European Committee for Treatment and Research in Multiple Sclerosis, Swedish Research Council, the Swedish Brain Foundation, the Swedish Cancer Society, Knut and Alice Wallenberg Foundation, the Swedish Society for Medical Research, the Ming Wai Lau Centre for Reparative Medicine, “La Caixa” Foundation, NIH, the National Institute on Aging, the Olav Thon Foundation and Karolinska Institutet.


“Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility.” Mandy Meijer*, Eneritz Agirre*, Mukund Kabbe, Cassandra A. van Tuijn, Abeer Heskol, Chao Zheng, Ana Mendanha Falcão, Marek Bartosovic, Leslie Kirby, Daniela Calini, Michael R. Johnson, M. Ryan Corces, Thomas J. Montine, Xingqi Chen, Howard Y. Chang, Dheeraj Malhotra, and Gonçalo Castelo-Branco, Neuron, online January 28, 2022, doi: 10.1016/j.neuron.2021.12.034

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