Monday, January 17

Weight loss may repair the brain after stroke in diabetes

Dimitra Karampatsi, PhD Student

– This suggests that people with diabetes might have a better prognosis after a stroke, if weight loss will be given a high priority after diabetes is diagnosed, says Dimitra Karampatsi, MSc and PhD student at the Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet (KI SÖS) and first author of the study.

The researchers now plan to go ahead and study the association in a clinical registry study.

– This important finding needs to be further explored in clinical studies to enhance the treatment of our type 2 diabetic patients, adds Alexander Zabala, co-author, MD, PhD student at KI SÖS and Physician at Vo Acute Internal Medicine and Neurology at Södersjukhuset.

The study has been conceived by Vladimer Darsalia and Cesare Patrone at The NeuroCardioMetabol Group, Department of Clinical Science and Education, Södersjukhuset and is the result of a collaborative effort with the Center for Brain Repair, Department of Clinical Neuroscience, Sahlgrenska Academy at the University of Gothenburg and the Internal Medicine Unit at Södersjukhuset.

Funders of the study were The Swedish Research Council, Diabetesfonden, EFSD, STROKE-Riksförbundet, ALF, Hjärnfonden, Ulla Hamberg Angeby och Lennart Angebys Stiftelse and the Swedish Heart-Lung foundation.


Diet-induced weight loss in obese/diabetic mice normalizes glucose metabolism and promotes functional recovery after stroke
Dimitra Karampatsi, Alexander Zabala, Ulrika Wilhelmsson, Doortje Dekens, Ellen Vercalsteren, Martin Larsson, Thomas Nyström, Milos Pekny, Cesare Patrone, Vladimer Darsalia
Cardiovascular Diabetology, 22 Dec 2021

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